It has long been thought, quite reasonably, that the immigrant Blue family lines were related in ancestral Argyll. The Reverend Douglas Kelly wrote about possibilities in his "The Scottish Blue Family in North America" (2007), a considerably revised and enlarged edition of his "The Scottish Blue Family From Carolina to Texas" (1982).
During this decade, DNA research has been phenomenal. We now know incontrovertibly that the Lakeview Blues and the Malcolm Blue family of Cumberland County share a common ancestor.
Catherine Ann Blue (Kelly, p. 491), my wife, and her brother Raymond Eugene Blue, Jr., of North Carolina and Clinton Lamon Blue (p. 187) of a Louisiana family have closely matching Y-Chromosomes at the 67-Marker level, the highest currently reported by Family Tree DNA.
The percentages of probability for sharing a common ancestor are:
Generations Percentage 4 9.51% 8 47.44% 12 79.42% 16 93.76% 20 98.40% 24 99.63% (Figures are reported for each of 24 generations).
Clinton, Catherine, and Raymond are all the seventh generation from their ancestral Blue immigrant.
Paternally, the Blues belong to genetic family Oisin (pronounced O'Sheen), the largest clan in Europe (see its website). They descend from one man in Spain during the last Ice Age. Oisin's DNA had a mutation that changed him from Haplogroup Ria to Rib (see Haplogroup website). Paternally, these Blues are aboriginal Europeans, the Cro-Magnons (of the cave paintings) and Celts, that is, Celtiberians. They predominate in various places, including northwestern Spain, the United Kingdom, and Ireland. This writer, also Celtiberian, Border Scot, and apparent Rhinelander, shares this clan.
The writer's DNA results include large numbers of current persons with whom he shares a common ancestor at various times in the past. The Blue results are "skimpy" when compared to this writer's DNA results. Indeed, Family Tree DNA paused when upper level matches were virtually absent. The subsequent report was bereft of matches. Later, Clinton Lamon Blue appeared at Y-Chromosome 67-Marker level (the levels are 12, 25, 37, and 67).
The results of the related National Geographic Genome Project offer a possible explanation. The Blue genetic ancestry is found in only three places: Spain, the Canary Islands, and Wales. This result suggests that the Blues migrated by sea. Travel by sea is known to have occurred far back in ancient times. In contrast, the Erwin genome proceeded by land and accumulated large numbers.
For further explanations, see the websites for Family Tree DNA and the very readable books by English scientist Bryan Sykes who made many of the discoveries: The Seven Daughters of Eve (2001), Adam's Curse (2004), and Saxons, Vikings, and Celts (2006).